May 15, 2020

CBD and the Endocannabinoid System part 1 with Dr. Nick Jikomes

CBD and the Endocannabinoid System part 1 with Dr. Nick Jikomes
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One Thing with Dr. Adam Rinde

Cannabadiol  (CBD)is a specific plant compound that is  a viable treatment option for many health conditions. However so many of us don’t really understand it. There is a huge need for health consumers , scientist, and physicians to learn the intricacies of this important medicine.

In this episode which is part 1 of a 2 part interview;  I welcome Dr. Nick Jikomes, a  well-known scientist and cannabis industry leader .

Dr. Jikomes is a neuroscientist and analytical expert in the world of plant medicine. Through his work at Leafly (a world-renown science driven cannabis database and resource) he had helped people learn the science behind cannabis and how to apply that for specific health outcomes.

 In episode one we discuss :

  • An overview view of the Endocannabinoid system (ECS)
  • Endocannabinoid systems role in homeostasis
  • Endocannabinoid receptors CB1 and CB2 and their unique functions
  • Endogenous Cannabinoids Anandamide, 2-AG
  • Diet and Lifestyle influences on the ECS
  • The differences between THC dominant, CBD dominant, and balanced strains
  • The difference between Marijuana, Hemp-derived full spectrum CBD, and synthetic/purfied CBD
  • Chemical Phenotypes of Cannabis

This episode sets up further discussion in part 2 about clinical applicatons

About our Guest

Nick Jikomes, PHD

With a decade of scientific research experience, Dr. Jikomes works to ensure that Leafly takes a data-driven approach to product development, content and strategy. As Director of Science & Innovation, h lead efforts in research and data strategy. This includes forging strategic partnerships with cannabis testing facilities and licensed producers to incorporate laboratory data into Leafly’s massive consumer-facing platform. By combining the latest scientific research insights and data science techniques, he works to enhance the Leafly platform by creating exciting new product exploration and recommendation tools for consumers.


Before joining Leafly, Dr. Jikomes completed ten years of formal training in biological research and science education and I earned a B.S. in Genetics from the University of Wisconsin-Madison and a Ph.D. in Neuroscience from Harvard University.


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